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SYNVISC 2ML

$75.00

1 Syringe x 2ml per pack

Description

SYNVISC (CANADIAN PACKAGING-ENGLISH) (HYLAN)

Designed to treat osteoarthritis knee joint pain by restoring the combined elasticity and viscosity within the joint.

Hylane G-F 20 is available in two forms:

Synvisc, 2 ml: 2.25 ml glass syringe (cans of 1 [ACL 3401078489921] and 3 [ACL 3401076479283]).

Synvisc-One, 6 ml: 10 ml glass syringe (ACL 3401048640222).

Hylan G-F is a sterile, pyrogen-free, viscoelastic liquid containing the hylan A and hylan B polymers produced from a highly purified bird extract. Hylans are derivatives of hyaluronan (sodium hyaluronate), and they are composed of recurrent disaccharide units of N-acetylglucosamine and sodium glucuronate.

Hylan A has an average molecular weight of 6,000,000 daltons and hylan B is a hydrated gel. Hylan G-F contains hylan A and hylan B (8.0 mg ± 2.0 mg / ml) in a physiological saline solution of buffered sodium chloride (pH 7.2 ± 0.3).

Composition:
For 1 ml (Hylan G-F 20): hylan 8.0 mg, sodium chloride 8.5 mg, disodium phosphate 0.16 mg, sodium dihydrogen phosphate 0.04 mg, water for injections qs.

Synvisc contains 2 ml of Hylan G-F 20. Synvisc-One contains 6 ml of Hylan G-F 20.

properties:
Hylan G-F is biologically similar to hyaluronan. Hyaluronan is a component of the synovial fluid that gives it its viscoelasticity. The mechanical (viscoelastic) properties of Hylane G-F, however, are superior to those of synovial fluid and hyaluronan solutions of similar concentrations. Hylane GF 20 has an elasticity (storage coefficient G ‘) at 2.5 Hz of 111 ± 13 pascals (Pa) and a viscosity (loss coefficient G’ ‘) of 25 ± 2 Pa. The elasticity and the viscosity of the synovial fluid of the knee of subjects aged 18 to 27 years measured with a method comparable to 2.5 Hz are G ‘= 117 ± 13 Pa; G ” = 45 ± 8 Pa. Hylans are metabolized in the body by the same route as hyaluronan and the products of their degradation are not toxic.

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